Oral pigmented lesions: a pragmatic approach to diagnosis and management Faculty Dental Journal Oral Mucosal Melanosis IntechOpen Simple cryosurgical treatment of the oral melanotic macule ScienceDirect Pigmented Lesions of the Oral Mucosa Springer Nature Link Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.