Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Do You Reach for Tylenol Often? Whether it's for pain, headaches, or fever Tylenol (acetaminophen) is one of the most commonly used medications. But here's something most people don't realize Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation