Glucose 6 Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Pathology of G6PD deficiency Pathology Made Simple Clinical Pharmacology & Toxicology Pearl of the Week