Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden Scientific Reports Glutathione, Tylenol & Your Health: What You Should Know Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect
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tylenol suppresses glutathione Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. No cause has been