Understanding Activation and Protandim Nrf2 for Reducing Oxidative Stress Constantly getting asked about Protandim. Here is my response: Studies show it is helpful in reducing oxidative stress. I don't personally use it in my office, not necessarily because I don't like Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis ScienceDirect Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge Donovan 2012 Oxidative Medicine and Cellular Longevity Wiley Online Library The Effect of Protandim Supplementation on Athletic Performance and Oxidative Blood Markers in Runners PLOS One