What Caused These Multiple Hyperpigmented Macules of the Mouth? Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists Taint melanotic of the lip vaporization laser UNILASER MDICA ORAL MELANOTIC MACULE (OMM) (Also called focal melanosis labial melanotic macule) A benign, localized, flat pigmented lesion of the oral mucosa Caused by a focal increase in melanin production