Activating the NRF2 Pathway in Dogs: A Practical Approach to Supporting Cellular Resilience & Longevity by Reducing Oxidative Stress Constantly getting asked about Protandim. Here is my response: Studies show it is helpful in reducing oxidative stress. I don't personally use it in my office, not necessarily because I don't like Metabolic features of cancer cells in NRF2 addiction status Biophysical Reviews Springer Nature Link Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two Stage Skin Carcinogenesis as a Model PLOS One Understanding Activation and Protandim Nrf2 for Reducing Oxidative Stress