Semaglutide with B12 for Weight Loss: What Results to Expect Dr. Brandon Richland, MD Safe IM Injection Site Intramuscular injection should always be given in the **upper outer quadrant of the gluteal region** to prevent sciatic nerve injury. Key nursing points: Upper outer quadrant = B12 vitamin Store How to inject B12 in your arm B12 Injections at Home Safety Guide for Self Administration Infusion For Health How to Give Yourself Intramuscular (IM) Injections Patients & Families UW Health