Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure ScienceDirect Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Sex differences in glutathione metabolism and acetaminophen toxicity Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Glutathione Inj 600 Mg Pinkline Exports