Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis ScienceDirect Layout 4 Layout 4 Constantly getting asked about Protandim. Here is my response: Studies show it is helpful in reducing oxidative stress. I don't personally use it in my office, not necessarily because I don't like Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two Stage Skin Carcinogenesis as a Model PLOS One