Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast cell activators. MC = mast cell; LMWM = low molecular weight Download Scientific Diagram IRE1 determines ferroptosis sensitivity through regulation of glutathione synthesis Nature Communications The allergic cascade. Mast cell mediators, including cytokines, cause Download Scientific Diagram