Understanding Activation and Protandim Nrf2 for Reducing Oxidative Stress Glutathione S transferase pi expression regulates the Nrf2 dependent response to hormetic diselenides ScienceDirect Annmarie Valenti (AValenti762) Profile Pinterest Constantly getting asked about Protandim. Here is my response: Studies show it is helpful in reducing oxidative stress. I don't personally use it in my office, not necessarily because I don't like Protandim Dual Synergizer, Protandim Nrf1 Synergizer (60 Capsules) + Protandim Nrf2 Synergizer (30 Caplets) Mitochondrial Supplements