In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency The Medical Biochemistry Page pharmacology Anti malarial drugs and g6pd deficiency Biology Stack Exchange G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione (